A: Yes. Rabbits of either sex should be spayed or neutered. Without the surgery, rabbits may get cancer in their reproduction organs. On the less serious side of things, unspayed and unneutered rabbits may acquire annoying habits such as biting and spraying urine. The best age to get a female rabbit spayed is around 6 months old. They could be spayed earlier, but rabbits are delicate, so six months is the safest age to get them spayed or neutered at. For male rabbits, the best age to get them neutered at is 5 months old (1). If your rabbit is older than this, it can still be spayed or neutered easily. The only problem is that if your alter them later that 5 or 6 months, they may have already reproduced (therefore contributing to the overpopulation of rabbits) or developed irritating habits.